Generic Actos (Pioglitazone)
Actos
Actos (Pioglitazone) is used to control high blood sugar in type 2 diabetes (non-insulin-dependent diabetes mellitus).
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15 mg x 30 pills
$22.99
$0.77
$0.00
15 mg x 60 pills
$36.99
$0.62
$9.00
15 mg x 90 pills
$50.99
$0.57
$18.00
15 mg x 120 pills
$60.99
$0.51
$31.20
15 mg x 180 pills
$81.99
$0.46
$55.80
15 mg x 360 pills
$139.99
$0.39
$136.80
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30 mg x 10 pills
$15.99
$1.60
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30 mg x 30 pills
$39.99
$1.33
$8.10
30 mg x 60 pills
$72.99
$1.22
$22.80
30 mg x 90 pills
$97.99
$1.09
$45.90
30 mg x 120 pills
$117.99
$0.98
$74.40
30 mg x 180 pills
$158.99
$0.88
$129.60
30 mg x 360 pills
$241.99
$0.67
$334.80
Product Description
Bendroflumethiazide; Nadolol: Moderate Increased frequency of blood glucose monitoring may be required when a Actod blocker is given with antidiabetic agents. Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate: Minor Patients receiving Actod agents should be periodically monitored for changes in glycemic control when Acto therapy is instituted or discontinued. Dabrafenib: Major The concomitant use of dabrafenib and pioglitazone may lead to decreased pioglitazone Actps and loss of efficacy. Use pioglitazone with caution in Adtos geriatric patient, especially those patients with pre-existing cardiac or kidney disease, due to a risk for heart failure. Subscribe to Drugs. Estradiol: Minor Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. Members can take a free confidential hearing test by phone. Phenelzine: Moderate Animal data indicate that monoamine oxidase inhibitors MAO inhibitors may stimulate insulin secretion. Niacin, Niacinamide: Moderate Niacin nicotinic acid interferes with glucose metabolism and can result in hyperglycemia. Authorisation details. Required field. American Society of Health-System Pharmacists. The French Medicines Agency pulled Actos as well as Competact — a drug that combines Actos and Metformin, another diabetes drug — after a government-funded study found the drugs increased bladder cancer risk. On June 15, the U. Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate: Minor Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. In a year observational follow-up of the PROactive Study, researchers investigated the occurrence of cardiovascular outcomes and malignancies after the PROactive clinical trial period ended. These women may Actos at increased risk of Acto Bone fractures, usually in Axtos hand, upper arm or foot, have been seen in some women when taking Actos. The results showed that after adjusting for age, sex, and use of other anti-diabetic medications, there was a statistically significant increase in the risk for bladder cancer in patients exposed to pioglitazone compared to patients exposed to other anti-diabetic agents HR 1. Pioglitazone and all other drugs of its class thiazolidinediones are absolutely contraindicated in patients with heart failure. Food and Drug Administration FDA informed the public that use of Actos for more than one year may be associated with an increased risk of bladder cancer. On June 9, the French Agency for the Safety of Health Products decided to withdraw pioglitazone due to high risk of bladder cancer. Your doctor will tell you how many Actos tablets you should take. Follow your doctor's instructions very closely. Moderate Closely monitor blood glucose levels if pibrentasvir is administered with antidiabetic agents. Your physician or other health professional should see you on at least a monthly basis until your optimal dose is reached, and after Actos evaluate your hemoglobin A1c and physical condition at day intervals. Javascript must be enabled to use this site. This medicine helps most people with type 2 diabetes not controlled by diet, but it may have unwanted side effects in some people. Takeda, a Japanese company, said the settlement would resolve most of the product-liability lawsuits related to Actos. Glitazones decrease insulin resistance. Do not restart pioglitazone in patients who have serum ALT more than 3 times the ULN with serum total bilirubin more than 2 times the ULN and do not have alternative etiologies for the abnormalities. Octreotide: Moderate Monitor patients receiving octreotide concomitantly with insulin or other antidiabetic agents for changes in glycemic control and adjust doses of these medications accordingly. The purpose of this study is to examine whether pioglitazone versus placebo can reduce the conversion rate of impaired glucose tolerance IGT to type 2 diabetes mellitus. The study also suggested a modest trend towards higher risk with increasing duration of use, but this trend was not statistically significant; it could have been due to chance. The French Medicines Agency pulled Actos as well as Competact — a drug that combines Actos and Metformin, another diabetes drug — after a government-funded study found the drugs increased bladder cancer risk. Finally, the release of adipocytokines such as tumor necrosis factor alfa, resistin, and adiponectin is regulated to promote insulin sensitivity. Offer Details. Segesterone Acetate; Ethinyl Estradiol: Minor Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, may decrease antidiabetic agent dosage requirements. First approved inActos is currently the only Actoz in this medication class to be widely available in the US and Europe. Clinically Actod interactions may occur when administered with drugs that inhibit or induce CYP2C8. Pioglitazone Actoa a CYP2C8 substrate. Ranitidine: Minor Concentrations of pioglitazone may be decreased with concomitant use of ranitidine. A signed retainer agreement from you is necessary before we will represent you in any case. Atazanavir; Cobicistat: Moderate New onset diabetes mellitus, exacerbation of diabetes mellitus, and hyperglycemia due to insulin resistance have been reported with use of anti-retroviral protease inhibitors. This section does not cite any sources. Based on the results of the French study, France has suspended the use of pioglitazone and Germany has recommended not to start pioglitazone in new patients. Based on the results of this study, France has suspended the use of pioglitazone and Germany has recommended not to start pioglitazone in new patients. Some people taking this medicine have had bladder Actoa, but it is not clear if pioglitazone was the actual cause. Dabrafenib: Major The concomitant use of dabrafenib and pioglitazone may lead to decreased pioglitazone exposure and loss of efficacy. Pioglitazone is only active in Axtos presence of insulin. If you or a loved one are suffering Atos bladder cancer and have taken Actos, Actoplus met, Actoplus met XR, or duetact, you may be entitled to compensation. Talk with your doctor about your specific risk. Altered blood glucose control, resulting in serious symptomatic hypoglycemia, has Actos reported in diabetic patients receiving antidiabetic agents in combination with direct acting antivirals, such as pibrentasvir. Pentamidine: Moderate Pentamidine can be harmful to pancreatic cells. Pioglitazone should not be used in patients with active bladder cancer. Fenofibric Acid: Moderate Dose reductions and increased frequency of glucose monitoring may be required when antidiabetic agents are administered with fibric acid derivatives e. Octreotide alters the balance between the counter-regulatory hormones of insulin, glucagon, and growth hormone, which may result in hypoglycemia or hyperglycemia. Many non-prescription drug products may be formulated with alcohol; instruct patients to scrutinize product labels prior to consumption. Pioglitazone is also indicated for combination with insulin in type-2 diabetes mellitus patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance. The risk of edema, weight gain, or congestive heart failure is increased when higher doses of pioglitazone are used in combination with insulin in patients at risk of heart failure. For the full list of all side effects reported with Actos, see the package leaflet. In vitro, dabrafenib is an inducer of CYP2C isoenzymes via activation of the pregnane X receptor and constitutive androstane receptor nuclear receptors. Views Read Edit View history. Acos on ongoing European review of pioglitazone—containing medicines. Activation of the PPAR-gamma receptor enhances insulin sensitivity through several mechanisms. Octreotide: Moderate Monitor patients receiving octreotide concomitantly with insulin or other antidiabetic agents for changes in glycemic control and adjust doses of these medications accordingly. AActos Primary Completion Date :. While you are taking Actos Things you must Actos It is important that you remember to take Actos daily and at the dose prescribed by your doctor. Join or Renew Today! Skip to main content. Onset averaged approximately 63 days after initiating protease inhibitor therapy, but has occurred as early as 4 days after beginning therapy. This safety information is based on FDA's review of data from a planned five-year interim analysis of an ongoing, ten-year epidemiological study 1described in FDA's September ongoing safety review and in the Data Summary below. Some of the symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin. Available for Android and iOS devices. On June 9, the French Agency for the Safety of Health Products decided to withdraw pioglitazone due to high risk of bladder cancer.
Common use



Actos is used to control high blood sugar in type 2 diabetes (non-insulin-dependent diabetes mellitus). This form of the illness is usually caused by inability of the body to respond correctly to insulin: either the body does not produce enough insulin or the cells ignore the insulin. Insulin is the natural hormone that helps to transfer sugar out of the blood and into the cells, where it is metabolized to energy. Actos works by improving the response of the body to insulin, rather than increasing its insulin output. Actos also reduces the production of unneeded sugar in the liver.

It is possible to use Actos (and rosiglitazone maleate as well) alone or together with insulin injections or other oral diabetes medications such as glipizide, glyburide, metformin hydrochloride.



Dosage and directions

Take this medication by mouth, with or without food, usually one time a daily. Follow all directions of your health care advisor as dosage is based on your medical condition, possible reaction to therapy, and can be corrected if you are treated by other anti-diabetic medications. Take this drug each time the same day as this way you will get the most benefit from it. Regularly monitor blood glucose levels. It may take up to 2 to 3 months before the full benefit is realized. Take all other medications for diabetes according to recommendations of your doctor.



Precautions

Before taking Actos, tell your doctor or pharmacist if you are allergic to it; if you are allergic to other "glitazones" (such as rosiglitazone, troglitazone); or if you have any other types of allergy. Do not use Actos if you have certain medical conditions. Before to start treatment with Actos, notify you doctor or pharmacist if you have: type 1 diabetes (insulin-dependent diabetes), heart failure (acute congestive heart failure) either newly diagnosed or worsening, dangerously high blood glucose (diabetic ketoacidosis), liver dysfunctions. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (chronic congestive heart failure), liver problems, fluid in your lungs, swelling (edema), anemia. Extremely low or high blood sugar levels may cause blurred vision, dizziness, or drowsiness; be cautious engaging in activities requiring alertness for example driving or operating machinery. Limit alcohol as much as possible when you are treated with this medication because it can increase the risk of developing hypoglycemia. If you have fever, infection, injury or surgery, it may complicate controlling of your blood sugar. Consult your doctor, as you may need correction of dose or a change in your medication may be required. Women with certain fertility problems may have changes in the menstrual cycle (ovulation) taking this medication. Consult your doctor or pharmacist about prescription of reliable contraception while you are taking Actos. This medication should be used in pregnant women only in life threating conditions. Discuss its risks and benefits with your physician. If you are pregnant your doctor may substitute insulin for Actos. Follow all instructions carefully. There are no reports whether this drug excretes with breast milk. Breastfeeding is not advised while using this drug. Before to start breastfeeding consult your physician.



Possible side effects

Actos side effects include rapid heartbeat, sweating, confusion, blurred vision, headache, numbness or tingling of the mouth, weakness,shakiness, dizziness, tiredness, paleness and sudden hunger.



Missed dose

If you miss a dose, take it as soon as you remember unless just a few hours remained till your next dose. Skip the missed dose and return the dosing schedule in case it is near the time of the next dose. Do not double the dose to make up the dose you missed.



Overdose

Seek emergency medical attention if you think you have taken too much of this medicine. You may have signs of low blood sugar, such as hunger, weakness, dizziness, headache, irritability, drowsiness, fainting, sweating, confusion, tremors, fast heartbeat, seizure (convulsions), or coma.



Drug interactions

Inform your health care advisor if you are taking any other anti-diabetic medications (insulin, metformin, or sulfonylureas such as glyburide), herbal/natural products (fenugreek, ginseng, gymnema). This medication is able to decrease the effectiveness of certain contraceptives which may result in pregnancy. Take care about additional form of reliable birth control while using Actos. Do not begin or discontinue intake of any medicine without doctor or pharmacist approval.



Storage

Store at room temperature in a tight container, away from moisture and humidity.





Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Doxycycline

Active Ingredients:

  • Doxycycline

Action mechanism and therapeutic effect of the medication:

Doxycycline is half-synthetic tetracycline antibiotic with a broad spectrum of antibacterial activity. Doxycycline exerts bacteriostatic action associated with suppressing the synthesis of proteins on ribosomes in microbial cell. Doxycycline is active against aerobic gram-positive bacteria Staphylococcus spp, Bacillus anthracis, Listeria monocytogenes; aerobic bacteria:Clostridium spp.

Medical indications: Doxycycline is indicated for the treatment of infections caused by sysceptible microorganisms:

  • ENT infections
  • Gastrointestinal infections
  • Infections of the upper and lower respiratory system
  • Skin and soft tissue infections
  • Urogenital infections
  • Syphilis (when unable to take penicillin)
  • Some respiratory or urinary tract infections (UTIs)
  • Plague
  • Cholera
  • Certain types of pneumonia
  • Chlamydia
  • Rocky Mountain spotted fever
  • Tularemia
  • Typhus fever
  • Tick fever
  • Gonorrhea
  • Lyme disease
  • Anthrax infection treatment
  • Rosacea treatment
  • Gum disease treatment
  • Malaria treatment

Doxycyline contradictions, precautions and warnings:

Doxycycline is contraindicated for use in:

  • Hypersensitivity to doxycycline and other components of the medication
  • Severe liver diseases
  • Severe kidney diseases
  • History of pseudo-membranous colitis
  • Pregnancy (Doxycycline is a pregnancy category D meaning that it can cause significant damage to the fetus)
  • Breastfeeding
  • Frequent yeast infections

Doxycyline side effects:

As with any other drug, side effects can occur with Doxycyline. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. The most common Doxycycline side effects include:

  • Decreased appetite
  • Vomiting
  • Stomach pain
  • Heartburn
  • Diarrhea
  • Photo-sensitivity
  • Nausea

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Doxycyline, please talk to your doctor or pharmacist.

Drug interaction:

Doxycyline can potentially interact with the following groups of drugs:

  • Aluminum, calcium, magnesium, or iron products
  • Bile-acid sequestrant cholesterol drugs
  • Barbiturates
  • Peniccilins
  • Oral typhoid vaccine
  • Birth control pills
  • Anti-diarrheal drug (Bismuth subsalicylate)
  • Bipolar disorder treatment (Carbamazepine)
  • HIV treatment (Maraviroc)
  • Retinoids
  • Blood thinners (Warfarin)
  • ACE inhibitor (Quinapril)
  • Aldosterone antagonist (Eplerenone)
  • Opioid pain killer (Fentanyl)
  • Anticonvulsant (phenytoin)

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Doxycyline which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.