Generic Clozaril (Clozapine)
Clozaril is an atypical antipsycotic. It is used to treat schizophrenia in patients who do not respond to other medicines.
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Product Description
Myocarditis, Clozarill, and Mitral Valve Incompetence Myocarditis inflammation of heart muscle and cardiomyopathy enlarged Cloozaril have rarely been reported. This is also known as Clozarril syndrome. This can lead to hospitalization or even death if constipation is not diagnosed and treated quickly. If Cloxaril miss a dose of clozapine, take Clizaril as soon as you remember, unless it is closer to Clozarl time of your next dose. The study recommends carbamazepine to not be used concurrently with clozapine due to increased risk of agranulocytosis. This list is not complete and many other drugs can interact with clozapine. Pancreatitis, hepatitis, cholestatic jaundice. Clozapinesold under the brand name Clozaril among others, [2] is an atypical antipsychotic medication. This medication should not be prescribed for other uses; ask your doctor or pharmacist for more information. It will probably take several weeks to see big enough changes in your symptoms to decide if clozapine is the right medication for you. If you are planning on becoming pregnant, notify your healthcare provider to best manage your medications. The pharmacy must have a copy of your blood counts to be able to dispense the medication. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with clozapine. When you start or stop taking Clozaril, your doctor may need to adjust the doses of any other medicines you take on a regular basis. Symptoms of EPS include restlessness, tremor, and stiffness. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. This is not a complete list of side effects and others may occur. Symptoms of these heart problems include shortness of breath, racing heart, flu-like symptoms, or chest pain. Your doctor will order the lab tests once a week at first and may order the tests less often as your treatment continues. Clozaril every known side effect, adverse effect, or drug interaction is in this database. Common side effects of Clozaril are drooling due to increased salivation, sedation, drowsiness, fast heart rate, weight gain, dizziness, vertigo, and constipation. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Crilly J March Clozapine may cause myocarditis swelling of the heart muscle that may be dangerous or cardiomyopathy enlarged or thickened heart muscle that stops the heart from pumping blood normally. Clozapine can lower blood cells that help your body fight infections, especially in women and older adults, and in people who are malnourished or have serious medical problems. It is important to take this medication exactly as prescribed. It is this monitoring requirement which serves as the basis for the Clozapine risk evaluation and mitigation strategy REMS. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Talk to your doctor if you do not take clozapine for 2 days or longer. Reasons for updating Change to section 2 - what you need to know - contraindications Change to section 2 - what you need to know - warnings and precautions Change to section 4 - possible side effects. Antagonists: AR-A Beta blockers e. Monitor patients for symptoms of potential complications associated with gastrointestinal hypomotility such as nausea, abdominal distension or pain, and vomiting. Tell your doctor if you Clozaril or have had a heart attack, heart failure, or a slow, irregular heartbeat or are taking medications Cloozaril high blood pressure. Clozapine rebalances dopamine and serotonin to improve thinking, mood, and behavior. What special precautions should I follow? Follow your doctors instructions carefully and do not change your dose unless your doctor tells you. Skin reactions. Tardive dyskinesia TD is a side effect that develops with prolonged use of antipsychotics. If it becomes necessary to stop this medication, the dose should be reduced gradually to prevent withdrawal effects. Your doctor will probably want to decrease your dose Clozarril. Molecular Psychiatry. Tell your doctor about all medicines you use, Clozsril those you start or stop using during your treatment with clozapine. For Clozaril with diseases, conditions, or medications that could exacerbate these effects, complete fall risk assessments when initiating antipsychotic treatment and recurrently for patients on long-term antipsychotic therapy. Aspiration of ingested food, pneumonia and lower respiratory tract infection which may be fatal. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. The data suggest that clozapine may be more likely to cause adverse metabolic effects than some of the other atypical antipsychotics. QT prolongation is a serious, life-threatening condition that can cause fainting, seizures, and sudden death. The study recommends carbamazepine to not be used concurrently with clozapine due to increased risk of agranulocytosis. Endocrine disorders. Clozapine is an antipsychotic medicine works by changing the actions of chemicals in the brain. Medications used to lower blood pressure may increase this effect and increase your risk of falling. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. Archived from the original on 9 February Clozapine is associated with a relatively high risk of low white blood cells agranulocytosisa condition of suppressed immunity which may result in death. The major metabolite, norclozapine desmethyl -clozapineis pharmacologically active. A decrease in the number of platelets a blood cell essential for the clotting of blood has occurred in isolated cases. Your dose of clozapine may need to be adjusted, especially in the first few weeks. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Respiratory, thoracic and mediastinal disorders. Archived from the original PDF on 8 November There are hundreds of drugs which are known to interact with Clozaril in major, moderate, or mild ways, so let your doctor know what other medications you are taking before you begin taking the medication. Hyperosmolar coma, ketoacidosis, severe hyperglycaemia, hypercholesterolemia, hypertriglyceridemia. Do you or your family have a history of fits? Clozapine may cause problems in newborns following delivery if it is taken during the last months of pregnancy. Wynne J, Braunwald E. Monitoring must continue throughout treatment and for 4 weeks after complete discontinuation of Clozaril. Initial dose: Fill a cup with water and place the tip of the oral syringe into the water in the cup. If you have glaucoma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Anticholinergic effects Clozaril exerts anticholinergic activity, which may produce undesirable effects throughout the body. Muscarinic acetylcholine receptor modulators. Subscribe to our newsletters. Clozapine is an antipsychotic medicine works by changing the actions of chemicals in the brain. Click on this link to Download PDF directly. Histamine receptor modulators. While still holding the oral syringe in the bottle, carefully turn the bottle upwards so the syringe is on top. Diabetes: Clozapine may cause an increase in blood sugar levels and glucose tolerance may change. An interaction between two medications does not always mean that you must stop taking one of them. The Creation of Psychopharmacology. If you have glaucoma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Maintain contact with your doctor and seek medical attention if necessary when discontinuing the drug. Seizure Symptoms, Types, and Causes. IUPAC name. Common Clozaril effects include constipationbed-wetting, night-time droolingmuscle stiffnesssedationtremorsorthostatic hypotensionhyperglycemia, and weight gain. Published on PsychCentral. New York: McGraw-Hill. Free text change information supplied by the pharmaceutical company 3. This medicine may increase the risk of death in older adults with dementia-related conditions. The risk increases with longer treatment and is higher in seniors, especially senior women. The risk of developing extrapyramidal symptoms, such as tardive dyskinesia is below that of typical antipsychotics; this may be due to clozapine's anticholinergic effects. Clozapine induces the release of glutamate and D-serinean agonist at the glycine site of the NMDA receptorfrom astrocytes[63] and reduces the expression of astrocytic glutamate transporters. While holding the oral syringe in place, carefully turn the bottle upside down. Clozapine is in a class of medications called atypical antipsychotics. Food and Drug Administration Alert:. What is the typical dose that would be prescribed to someone taking Clozaril?
Common use

Clozaril is an atypical antipsycotic. It is used to treat schizophrenia in patients who do not respond to other medicines. It decrease the risk of suicidal behavior. It affects certain chemicals in the brain.

Dosage and directions

Take Clozaril as prescribed by your doctor. Take it with or without food. Take with food to reduce stomach irritation if stomach upset occurs. Continue to take the medicine even if you feel well. Do not stop taking it suddenly without your doctor's advice.


Tell your doctor about all your conditions, especially if you are pregnant or plan to become pregnant, breastfeeding, if you have any allergies, if you have a history of blood clots, blood problems, high blood cholesterol levels, heart problems, or lung or breathing problems, if you have a history of an enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel problems; or dementia, if you have poor health, diabetes, or a family member with diabetes, or you are very overweight, if you have decreased activity of enzymes that metabolize certain medicines.


You should not to take Clozaril if you have allergy to it, you have severe drowsiness, you have uncontrolled seizures (epilepsy) or loss of bowel muscle movement (paralytic ileus), you have bone marrow problems, other blood cell problems, or a history of blood problems caused by Clozaril, you are taking other medicines that may cause blood problems.

Possible side effects

The most common side effects are dry mouth, headache, dizziness, heartburn, increased sweating or saliva production, lightheadedness when you stand up; nausea; strange dreams; trouble sleeping; weight gain.

Severe side effects include: severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; calf pain or tenderness; chest pain; confusion; dark urine; decreased coordination; fainting; fast or irregular heartbeat; fever, chills, or sore throat; increased hunger, thirst, or urination; infection; involuntary movements of the tongue, face, mouth, or jaw (tongue sticking out, puffing of cheeks, mouth puckering, chewing movements); loss of appetite; numbness of an arm or leg; rapid breathing; restlessness; seizures; severe headache, dizziness, or vomiting; severe or persistent nausea or constipation; severe stomach pain; shortness of breath; stiff muscles; sudden, unusual weight gain; swelling of the hands, ankles, or feet; tremor; trouble swallowing; uncontrolled muscle movements; unusual mental or mood changes; unusual tiredness or weakness; vision changes; vomiting; yellowing of the skin or eyes.

Drug interaction

Tell your doctor about all medicines you are taking and especially: benzodiazepines (lorazepam) or other medicines for mental or mood problems because the risk of heart or breathing problems may be increased; cimetidine, erythromycin, quinolone antibiotics (ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they may increase the risk of Clozaril's side effects; barbiturates (phenobarbital), hydantoins (phenytoin), nicotine, or rifampin because they may decrease Clozaril's effectiveness ; antiarrhythmics (eg, propafenone, quinidine), anticholinergics (benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines (chlorpromazine), or tricyclic antidepressants (amitriptyline) because the risk of their side effects may be increased by Clozaril.

Missed dose

If you miss a dose of Clozaril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking a dose of Clozaril for more than 2 days do not start taking it again. Contact your doctor right away for instructions.


Symptoms of overdose are drowsiness, slow or difficult breathing, dizziness, excessive salvation, fainting, coma, fast ot irregular heartbeats. If you suspect overdose seek medical attention immediately.


Store Clozaril at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clozaril out of the reach of children and away from pets.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.


Active Ingredients:

  • Doxycycline

Action mechanism and therapeutic effect of the medication:

Doxycycline is half-synthetic tetracycline antibiotic with a broad spectrum of antibacterial activity. Doxycycline exerts bacteriostatic action associated with suppressing the synthesis of proteins on ribosomes in microbial cell. Doxycycline is active against aerobic gram-positive bacteria Staphylococcus spp, Bacillus anthracis, Listeria monocytogenes; aerobic bacteria:Clostridium spp.

Medical indications: Doxycycline is indicated for the treatment of infections caused by sysceptible microorganisms:

  • ENT infections
  • Gastrointestinal infections
  • Infections of the upper and lower respiratory system
  • Skin and soft tissue infections
  • Urogenital infections
  • Syphilis (when unable to take penicillin)
  • Some respiratory or urinary tract infections (UTIs)
  • Plague
  • Cholera
  • Certain types of pneumonia
  • Chlamydia
  • Rocky Mountain spotted fever
  • Tularemia
  • Typhus fever
  • Tick fever
  • Gonorrhea
  • Lyme disease
  • Anthrax infection treatment
  • Rosacea treatment
  • Gum disease treatment
  • Malaria treatment

Doxycyline contradictions, precautions and warnings:

Doxycycline is contraindicated for use in:

  • Hypersensitivity to doxycycline and other components of the medication
  • Severe liver diseases
  • Severe kidney diseases
  • History of pseudo-membranous colitis
  • Pregnancy (Doxycycline is a pregnancy category D meaning that it can cause significant damage to the fetus)
  • Breastfeeding
  • Frequent yeast infections

Doxycyline side effects:

As with any other drug, side effects can occur with Doxycyline. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. The most common Doxycycline side effects include:

  • Decreased appetite
  • Vomiting
  • Stomach pain
  • Heartburn
  • Diarrhea
  • Photo-sensitivity
  • Nausea

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Doxycyline, please talk to your doctor or pharmacist.

Drug interaction:

Doxycyline can potentially interact with the following groups of drugs:

  • Aluminum, calcium, magnesium, or iron products
  • Bile-acid sequestrant cholesterol drugs
  • Barbiturates
  • Peniccilins
  • Oral typhoid vaccine
  • Birth control pills
  • Anti-diarrheal drug (Bismuth subsalicylate)
  • Bipolar disorder treatment (Carbamazepine)
  • HIV treatment (Maraviroc)
  • Retinoids
  • Blood thinners (Warfarin)
  • ACE inhibitor (Quinapril)
  • Aldosterone antagonist (Eplerenone)
  • Opioid pain killer (Fentanyl)
  • Anticonvulsant (phenytoin)

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Doxycyline which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.