Generic Colospa (Mebeverine)
Colospa causes relaxation of the muscles, preventing painful muscle spasms. The drug is used in the treatment of irritable bowel syndrome.
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Product Description
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Common use

Colospa is a musculotropic antispasmodic medication used in the treatment of irritable bowel syndrome. It is also indicated for treatment of gastrointestinal spasm caused by a primal organic disorder. Mechanism of its action consists in relaxing of gut muscles at the cellular level. Colospa blocks transfer of Na+ through fast channels of myocyte into th cell and also inhibits calcium-depot replenishment, thus it performs a dual effect on bowels causing them to relax. It does not affect muscles of bronchi or uterus. No significant inhibition of normal peristalsis has been observed. This drug is used to treat a spasm of gastrointestinal organs (including due to organic disease), intestinal colic, biliary colic, irritable bowel syndrome (symptomatic treatment of pain and cramps, and intestinal disorders and discomfort) in adults.

Dosage and directions

Recommended daily dose of Colospa is 135 mg (1 tablet) 3 times daily, preferably before meals. Gradually the dosage may be reduced when the desired effect has been obtained.


In pregnant patients Colospa is possible to use when expected benefit of treatment exceeds potential risk for the unborn baby. Avoid driving or be specially cautious when you need to drive or operate any machinery and mechanisms due to the possible dizziness caused by Colospa. Carefulness should be exercised in patients with paralytic ileus which is obstruction caused by failure of function of the intestine. This medicine is not recommended to treat children under 10 years of age. Discuss with your doctor if you suffer from inactivity of the bowel or allergic to any sugars before to take Colospa.


Hypersensitivity, porphyria.

Possible side effect

Any medication may affect different people individually, symptoms of allergy (hives, rash, swelling of face) may appear. If you need more information about any other possible risks associated with Colospa, you should consult your doctor or pharmacist.

Drug interaction

This medicine is not known to interact with other medication.

Missed dose

If you missed a dose take the medication as soon as you remember. If it is almost time of your next dose just skip its intake and return to your regular schedule.


Overdose symptoms are unknown or may appear as over excitation of the central nervous system. Anyway if consider that you took too much of this medication consult your doctor, as you may need medical help.


Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.


Active Ingredients:

  • Doxycycline

Action mechanism and therapeutic effect of the medication:

Doxycycline is half-synthetic tetracycline antibiotic with a broad spectrum of antibacterial activity. Doxycycline exerts bacteriostatic action associated with suppressing the synthesis of proteins on ribosomes in microbial cell. Doxycycline is active against aerobic gram-positive bacteria Staphylococcus spp, Bacillus anthracis, Listeria monocytogenes; aerobic bacteria:Clostridium spp.

Medical indications: Doxycycline is indicated for the treatment of infections caused by sysceptible microorganisms:

  • ENT infections
  • Gastrointestinal infections
  • Infections of the upper and lower respiratory system
  • Skin and soft tissue infections
  • Urogenital infections
  • Syphilis (when unable to take penicillin)
  • Some respiratory or urinary tract infections (UTIs)
  • Plague
  • Cholera
  • Certain types of pneumonia
  • Chlamydia
  • Rocky Mountain spotted fever
  • Tularemia
  • Typhus fever
  • Tick fever
  • Gonorrhea
  • Lyme disease
  • Anthrax infection treatment
  • Rosacea treatment
  • Gum disease treatment
  • Malaria treatment

Doxycyline contradictions, precautions and warnings:

Doxycycline is contraindicated for use in:

  • Hypersensitivity to doxycycline and other components of the medication
  • Severe liver diseases
  • Severe kidney diseases
  • History of pseudo-membranous colitis
  • Pregnancy (Doxycycline is a pregnancy category D meaning that it can cause significant damage to the fetus)
  • Breastfeeding
  • Frequent yeast infections

Doxycyline side effects:

As with any other drug, side effects can occur with Doxycyline. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. The most common Doxycycline side effects include:

  • Decreased appetite
  • Vomiting
  • Stomach pain
  • Heartburn
  • Diarrhea
  • Photo-sensitivity
  • Nausea

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Doxycyline, please talk to your doctor or pharmacist.

Drug interaction:

Doxycyline can potentially interact with the following groups of drugs:

  • Aluminum, calcium, magnesium, or iron products
  • Bile-acid sequestrant cholesterol drugs
  • Barbiturates
  • Peniccilins
  • Oral typhoid vaccine
  • Birth control pills
  • Anti-diarrheal drug (Bismuth subsalicylate)
  • Bipolar disorder treatment (Carbamazepine)
  • HIV treatment (Maraviroc)
  • Retinoids
  • Blood thinners (Warfarin)
  • ACE inhibitor (Quinapril)
  • Aldosterone antagonist (Eplerenone)
  • Opioid pain killer (Fentanyl)
  • Anticonvulsant (phenytoin)

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Doxycyline which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.