Generic Detrol (Tolterodine)
Detrol
Detrol is prescribed for treatment of spasms of the bladder muscles, overactive bladder characterized by symptoms of urinary urgency, frequency, and incontinence.
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1 mg x 30 pills
$76.99
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1 mg x 60 pills
$133.99
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1 mg x 90 pills
$186.99
$2.08
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1 mg x 120 pills
$229.99
$1.92
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1 mg x 180 pills
$316.99
$1.76
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1 mg x 360 pills
$574.99
$1.60
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2 mg x 10 pills
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2 mg x 30 pills
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2 mg x 60 pills
$117.99
$1.97
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2 mg x 90 pills
$159.99
$1.78
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2 mg x 120 pills
$191.99
$1.60
$132.00
2 mg x 180 pills
$258.99
$1.44
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Product Description
DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this Detrol la through its RSS feed. Detrll levels of other metabolites of tolterodine e. National Library of Medicine U. This product's label may have been updated. Upcoming Events 08 Apr. Detrol LA. Take exactly as prescribed by your doctor. Monthly newsletter. The primary metabolic route involves the oxidation of the 5-methyl group and is mediated by the cytochrome P 2D6 CYP2D6 and leads to the formation of a pharmacologically active metabolite, 5-HMT. Drug Class. Change in number of urge episodes per 24 hours at week 1, week 6 and 12 relative to baseline. In another clinical study, elderly volunteers aged 71 through 81 years were given tolterodine immediate release 2 or 4 mg 1 or 2 mg bid. Related Drugs. Detrol LA 4 mg was evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, week study. In another clinical study, elderly volunteers aged 71 through 81 years were given tolterodine immediate release 2 or 4 mg 1 or 2 mg bid. Detrol LA Capsules 2 mg were evaluated in 29 patients in a Phase 2 dose-effect study. Discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Erratum in: JAMA. Terms and conditions of use. Do not dispose of medications in wastewater e. A serious adverse event was reported by 1. These characteristics were balanced across treatment groups for all three studies. The primary efficacy assessment was change in mean number of incontinence episodes per week at week 12 from baseline. Swallow it whole. Detrol LA tolterodine tartrate Profile. Detro impairment can significantly alter the disposition of tolterodine immediate Detrol la. Profile Contact Information. QT c P msec manual. Medically reviewed by Drugs. Retrieved 22 December However, no overall differences were observed in safety between older and younger patients on tolterodine in the Phase 3, week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients is recommended. From Wikipedia, the free encyclopedia. Reports of aggravation of symptoms of dementia e. Drug Class. After oral administration, tolterodine is metabolized in Detdol liver, resulting in the formation of 5-hydroxymethyl tolterodine 5-HMTthe major pharmacologically active metabolite. The remainder of the population Detgol referred to as "extensive metabolizers. Other drugs can affect how your body Detrpl Detrol LA. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Detrol LA is a prescription medicine for adults used to treat the following symptoms due to a condition called overactive bladder :. Request a Quote. Detrol LA tolterodine tartrate is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency. In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole. Talk with your doctor and family members or friends about deciding to join a study. No mutagenic or genotoxic effects of tolterodine were detected in a battery of in vitro tests, including bacterial Detrol la assays Ames test in 4 strains of Salmonella typhimurium and in 2 strains of Escherichia coli, a gene mutation assay in LY mouse lymphoma cells, and chromosomal aberration tests in human lymphocytes. Based on limited data, tolterodine is excreted into the milk in mice in low amounts see Data. Myasthenia Gravis: If you have myasthenia gravis, tolterodine may make your symptoms worse. For a complete list, ask your doctor or pharmacist. Do not take in larger or smaller amounts or for longer than recommended. For patients Detrrol are taking drugs that are potent Dterol of CYP3A4 [e. Please Laa out the form below and our representative will get back to you shortly. Warfarin : In healthy volunteers, coadministration of tolterodine immediate release 4 mg 2 mg bid for 7 days and a single dose Detrpl warfarin 25 mg on day 4 had no effect on prothrombin time, Factor VII suppression, Lq on the pharmacokinetics of LLa. Because these spontaneously reported events are from the worldwide post-marketing experience, the frequency of events and the role of tolterodine in their causation cannot be reliably determined. It is not known whether tolterodine passes into breast milk or if it could harm a nursing baby. In vitro data show that tolterodine immediate release is a competitive inhibitor of CYP2D6 at high concentrations K i 1. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication. Administer Detrol LA with caution in patients with myasthenia gravis, a disease characterized by decreased cholinergic activity at the neuromuscular junction. If you are a consumer or patient please visit this version. Symptoms of a serious allergic reaction may include swelling of the face, lips, throat, or tongue. About About Drugs. Clinical Results Three placebo-controlled, 12 week studies were held involving a total of patients who received Detrol 2 mg twice daily and patients who received the placebo. Phase 4. Metabolism: Tolterodine is extensively metabolized by the liver following oral dosing. Stop taking the medication and seek immediate medical attention if any of the following occur:.
Common use

Detrol La contains tolterodine tartrate, the substance of cholinergic (acetyl-choline) receptor blockers class. The medication is used to reduce spasms of the bladder muscles, overactive bladder with symptoms of urge urinary incontinence, and frequency.



Dosage and direction

Detrol La is taken two times a day. The recommended initial dose is 2mg taken twice daily. Treatment by long-acting Detrol La should be started by 4mg daily dose. If it is not well tolerated it should be reduced to 2mg. Dose adjustment is needed for the patients with impaired liver or kidney function. Do not open Detrol La capsules, do not crush or chew them. Swallow the tablet whole.



Precautions

Discuss with your doctor about following conditions you may have: glaucoma, kidney or liver disease, myasthenia gravis, or a personal or family history of "Long QT syndrome." This medicine may change your thinking reactions or ability to concentrate. Be careful while driving or operating machinery.



Contraindications

Detrol La cannot be used to treat patients with uncontrolled narrow-angle glaucoma, obstruction to the flow of urine (urinary retention), poor emptying of the stomach (gastric retention), allergic reaction to the components of the drug in history.



Possible side effect

Besides allergic reactions (hives, facial swelling, rash, skin eruptions, difficulty breathing) Detrol La may cause chest pain, fast or uneven heart rate, confusion, painful or difficult urination, hallucinations, urinating less than usual or not at all.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medications you are using and especially about the drugs which may interfere with elimination of tolterodine by the liver which include: cyclosporine (Gengraf, Neoral, Sandimmune), clarithromycin (Biaxin), azithromycin (Zithromax), erythromycin, telithromycin (Ketek), pentamidine (NebuPent, Pentam), sparfloxacin (Zagam), itraconazole (Sporanox), ketoconazole (Nizoral), and miconazole (Monistat, Micatin), arsenic trioxide (Trisenox), chloroquine (Arelan) or halofantrine (Halfan), levomethadyl (Orlaam), or methadone (Dolophine, Methadose), vinblastine (Velban), medications used to treat psychiatric disorders such aschlorpromazine (Thorazine), mesoridazine (Serentil), pimozide (Orap), haloperidol (Haldol), or thioridazine (Mellaril), heart rhythm medicine such as disopyramide (Norpace), procainamide (Procan, Pronestyl), amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), sotalol (Betapace), quinidine (Cardioquin, Quinaglute).



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

Symptoms of overdose include blurred vision, dry mouth, and fast heartbeat.



Storage

Store at room temperature 15-30 C (59-86 F) away from moisture and heat.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Doxycycline

Active Ingredients:

  • Doxycycline

Action mechanism and therapeutic effect of the medication:

Doxycycline is half-synthetic tetracycline antibiotic with a broad spectrum of antibacterial activity. Doxycycline exerts bacteriostatic action associated with suppressing the synthesis of proteins on ribosomes in microbial cell. Doxycycline is active against aerobic gram-positive bacteria Staphylococcus spp, Bacillus anthracis, Listeria monocytogenes; aerobic bacteria:Clostridium spp.

Medical indications: Doxycycline is indicated for the treatment of infections caused by sysceptible microorganisms:

  • ENT infections
  • Gastrointestinal infections
  • Infections of the upper and lower respiratory system
  • Skin and soft tissue infections
  • Urogenital infections
  • Syphilis (when unable to take penicillin)
  • Some respiratory or urinary tract infections (UTIs)
  • Plague
  • Cholera
  • Certain types of pneumonia
  • Chlamydia
  • Rocky Mountain spotted fever
  • Tularemia
  • Typhus fever
  • Tick fever
  • Gonorrhea
  • Lyme disease
  • Anthrax infection treatment
  • Rosacea treatment
  • Gum disease treatment
  • Malaria treatment

Doxycyline contradictions, precautions and warnings:

Doxycycline is contraindicated for use in:

  • Hypersensitivity to doxycycline and other components of the medication
  • Severe liver diseases
  • Severe kidney diseases
  • History of pseudo-membranous colitis
  • Pregnancy (Doxycycline is a pregnancy category D meaning that it can cause significant damage to the fetus)
  • Breastfeeding
  • Frequent yeast infections

Doxycyline side effects:

As with any other drug, side effects can occur with Doxycyline. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. The most common Doxycycline side effects include:

  • Decreased appetite
  • Vomiting
  • Stomach pain
  • Heartburn
  • Diarrhea
  • Photo-sensitivity
  • Nausea

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Doxycyline, please talk to your doctor or pharmacist.

Drug interaction:

Doxycyline can potentially interact with the following groups of drugs:

  • Aluminum, calcium, magnesium, or iron products
  • Bile-acid sequestrant cholesterol drugs
  • Barbiturates
  • Peniccilins
  • Oral typhoid vaccine
  • Birth control pills
  • Anti-diarrheal drug (Bismuth subsalicylate)
  • Bipolar disorder treatment (Carbamazepine)
  • HIV treatment (Maraviroc)
  • Retinoids
  • Blood thinners (Warfarin)
  • ACE inhibitor (Quinapril)
  • Aldosterone antagonist (Eplerenone)
  • Opioid pain killer (Fentanyl)
  • Anticonvulsant (phenytoin)

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Doxycyline which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.