Generic Imuran (Azathioprine)
Imuran
Imuran suppresses immune system to treat autoimmune disease and is used in organ transplantation.
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25 mg x 60 pills
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25 mg x 90 pills
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25 mg x 120 pills
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50 mg x 120 pills
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50 mg x 240 pills
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50 mg x 270 pills
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Product Description
Medically reviewed by Drugs. Imuran on azathioprine your doctor may limit your alcoholic beverage intake. Keep all appointments with your health care provider and the laboratory. This generally occurs after 10 years of continuous use or with a lifetime dose of grams. Archived from the original on March 5, Views Read Edit View history. Antimetabolites purine synthesis inhibitors Azathioprine Mycophenolic acid pyrimidine synthesis inhibitors Leflunomide Teriflunomide antifolate Methotrexate. Show More. Your health care provider will probably order tests to check your blood cells and liver enzymes during your treatment with azathioprine. Women should discuss birth control with their primary care physicians or gynecologists. Azathioprine might also be used with other disease-modifying therapies to boost their effect when necessary. Red, warm, or draining sore. Error: This is required. Azathioprine can lower your immune system and increase your risk of getting infections. What to do if you miss a dose: If you miss a dose, take it as soon as you can. If you have questions about side effects, call your doctor. Tell your doctor and pharmacist about all of your drugs prescription or OTC, natural products, vitamins and health problems. If you think there has been an overdose, call your poison control center or get medical care right away. These effects usually happen within the first few weeks of starting the medication. Hydrocodone; Ibuprofen: Moderate NSAIDs should be used with caution in patients receiving Imyran as they may mask fever, pain, swelling and other signs and symptoms of an infection. What Imurn precautions should I follow? Further azathioprine dosage reduction or use of an alternative therapy is recommended for patients Immuran have low or Imurah thiopurine methyltransferase activity, as both the thiopurine methyltransferase and xanthine oxidase pathways are affected. Azathioprine is contraindicated for the treatment of rheumatoid arthritis in pregnant women. Inosine monophosphate dehydrogenase IMDH is required for one of the metabolic pathways of azathioprine and ribavirin is known to inhibit IMDH, thereby leading to the accumulation of the azathioprine metabolite, 6-methylthioinosine monophosphate 6-MTITP. When should I call my healthcare provider? Azathioprine is metabolized to 6-mercaptopurine 6-MP in the liver. Examples of live vaccines include:. Hale Pub. Take the missed dose as soon as you remember it. The starting dose is low and is slowly increased. Tolmetin: Moderate NSAIDs should be used with caution in patients receiving immunosuppressives as they may mask fever, pain, swelling and other signs and symptoms of an infection. Maintenance: use lowest effective dose; can decrease by 0.
Common use

Imuran contains azathioprine, which is an immunosuppressant. It is used to prevent rejection of kidney transplants, in treatment of rheumatoid arthritis, chronic active hepatitis, systemic lupus erythematosus, dermatomyositis, periarteritis nodosa, acquired hemolytic anemia, idiopathic thrombocytopenic purpura, gangrenous pyoderma, psoriasis, Crohn's disease, ulcerative colitis, myasthenia gravis, pemphigus (a chronic blistering skin disease), Reiter's syndrome (autoimmune condition that is caused by an infection in another part of the body), radiation dermatitis.



Dosage and direction

Take Imuran with food. The dose is administered individually for different conditions. Follow all instructions of your physician. Do not take more than one dose of Imuran at once.



Precautions

Do not stop taking this drug even if you do not feel improvement. Its effects may develop in several days or weeks. If you did not feel improvement of you symptoms after three months of treatment inform your doctor. The high risk of a draft rejection may remain even after several years of treatment. Blood tests for blood cell count should be exercised on a regular basis: each weak during first eight weeks of treatment. Avoid exposure to sun rays for a long time as this drug is able to increase risk of cancer. Regular examination of skin should be done. Patients with system diseases of joint tissues should not stop treatment without permission of a doctor not to provoke aggravation of their condition. This medication may decrease immunity status of unborn baby. Inform your doctor if you are pregnant or breastfeeding. Notify your doctor if you plan to be operated, have a fever, body aches, weakness, muscle pain, chills, sore throat, easy bruising or bleeding, mouth sores, severe nausea, vomiting, pale stools, darkened urine, and diarrhea.



Contraindications

This medicine cannot be administered to the patients with hypersensitivity to the components of the drug, inhibition of hematopoiesis (hypoplastic and aplastic anemia, leukopenia, lymphopenia, thrombocytopenia), hepatic failure, in pregnant and breastfeeding women, in children.



Possible side effect

Adverse reaction to Imuran mostly concern blood and gastrointestinal system. White blood cell count may decrease causing the increased risk of infection development. This effect most reverses when the dose is reduced or temporary discontinued. Nausea and vomiting caused by Imuran mostly disappear when its dose is diminished or divided in several intakes. In the patients with rheumatoid arthritis liver toxicity may develop. Other less common side effects include hair loss, joint pains, fatigue, and diarrhea.



Drug interaction

About 200 drugs are known to interact with Imuran. Inform your doctor about all prescribed and over-the-counter medications, herbal products and food supplements you take. The basic interactions of Imuran are described below. Imuran reduces effects of nondepolarizing muscle relaxants, increases neuromuscular block caused by suxametonium. Allopurinol (the medication for gout) inhibits azathioprine metabolism, increases its blood levels and toxicity. Imuran increases the effects of immunosuppressants, cytostatics. Anemia and leukopenia may develop if angiotensin-converting enzyme (ACE) inhibitors are used with Imuran. Imuran reduces blood concentrations and effects of indirect anticoagulants such as warfarin. Graft rejection may become a result of concomitant use of rifampicin and Imuran. When Imuran is used with co-trimoxazole a myelotoxic effect of azathioprine may increase.



Missed dose

If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. Skip the missed dose if it is almost time of your next dose. Do not try to compensate a missed dose by taking an extra one.



Overdose

If you think you have used too much of this medicine seek emergency medical attention right away. Very large doses of this Imuran may cause marrow hypoplasia, bleeding, infection, and death, nausea, vomiting, and diarrhea, mild leukopenia and mild liver impairments.



Storage

Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Do not use after expiration term.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Doxycycline

Active Ingredients:

  • Doxycycline

Action mechanism and therapeutic effect of the medication:

Doxycycline is half-synthetic tetracycline antibiotic with a broad spectrum of antibacterial activity. Doxycycline exerts bacteriostatic action associated with suppressing the synthesis of proteins on ribosomes in microbial cell. Doxycycline is active against aerobic gram-positive bacteria Staphylococcus spp, Bacillus anthracis, Listeria monocytogenes; aerobic bacteria:Clostridium spp.

Medical indications: Doxycycline is indicated for the treatment of infections caused by sysceptible microorganisms:

  • ENT infections
  • Gastrointestinal infections
  • Infections of the upper and lower respiratory system
  • Skin and soft tissue infections
  • Urogenital infections
  • Syphilis (when unable to take penicillin)
  • Some respiratory or urinary tract infections (UTIs)
  • Plague
  • Cholera
  • Certain types of pneumonia
  • Chlamydia
  • Rocky Mountain spotted fever
  • Tularemia
  • Typhus fever
  • Tick fever
  • Gonorrhea
  • Lyme disease
  • Anthrax infection treatment
  • Rosacea treatment
  • Gum disease treatment
  • Malaria treatment

Doxycyline contradictions, precautions and warnings:

Doxycycline is contraindicated for use in:

  • Hypersensitivity to doxycycline and other components of the medication
  • Severe liver diseases
  • Severe kidney diseases
  • History of pseudo-membranous colitis
  • Pregnancy (Doxycycline is a pregnancy category D meaning that it can cause significant damage to the fetus)
  • Breastfeeding
  • Frequent yeast infections

Doxycyline side effects:

As with any other drug, side effects can occur with Doxycyline. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. The most common Doxycycline side effects include:

  • Decreased appetite
  • Vomiting
  • Stomach pain
  • Heartburn
  • Diarrhea
  • Photo-sensitivity
  • Nausea

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Doxycyline, please talk to your doctor or pharmacist.

Drug interaction:

Doxycyline can potentially interact with the following groups of drugs:

  • Aluminum, calcium, magnesium, or iron products
  • Bile-acid sequestrant cholesterol drugs
  • Barbiturates
  • Peniccilins
  • Oral typhoid vaccine
  • Birth control pills
  • Anti-diarrheal drug (Bismuth subsalicylate)
  • Bipolar disorder treatment (Carbamazepine)
  • HIV treatment (Maraviroc)
  • Retinoids
  • Blood thinners (Warfarin)
  • ACE inhibitor (Quinapril)
  • Aldosterone antagonist (Eplerenone)
  • Opioid pain killer (Fentanyl)
  • Anticonvulsant (phenytoin)

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Doxycyline which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.