Generic Prandin (Repaglinide)
Prandin
Prandin is used to stimulate insulin secretion from the pancreas in treatment of type 2 of diabetes mellitus.
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Product Description
Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. This depolarizes the beta cells, opening the cells' calcium channelsand the resulting calcium influx induces insulin secretion. Prandin RSS. Hydroxychloroquine: Moderate Careful monitoring of blood glucose is recommended when hydroxychloroquine and antidiabetic agents, including the meglitinides, are coadministered. The hypoglycemic effect induced by IGF-1 activity may be exacerbated. Prandin comes in tablet form and is taken up to four times a day. Recipient's Email Separate multiple email address with a comma Please enter valid email address Recipient's email is required. A high protein content helps maintain muscle mass during a weight loss program. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Ethinyl Estradiol; Etonogestrel: Minor Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. Patients receiving antidiabetic agents should be closely monitored for signs indicating changes in diabetic control when therapy with progestins is instituted or discontinued. Subscribers will receive emails featuring new cardiovascular news. Take care not to let your blood sugar get too low. Patients receiving gemfibrozil are contraindicated from co-therapy with repaglinide. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. About About Drugs. Although this interaction has not been studied, predictions about the interaction can be made based on the metabolic pathway of repaglinide. Patients treated with pasireotide may experience either hypoglycemia or hyperglycemia. There is no information regarding the presence of PRANDIN in human milk, the effects on the breastfeeding infant, or the effects on milk production. Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Ephedrine: Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Simvastatin; Sitagliptin: Moderate Coadministration of may lead to an increase in repaglinide. Follow the directions on your prescription label. Gemfibrozil inhibits CYP2C8 and causes a significant increase in repaglinide blood levels. Hydrocodone; Phenylephrine: Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Use repaglinide regularly to get the most benefit. Dextromethorphan; Guaifenesin; Phenylephrine: Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Constituents in garlic might have some antidiabetic activity, and may increase serum insulin levels and increase glycogen storage in the liver. The hypoglycemia or hyperglycemia which occurs during octreotide acetate therapy is usually mild, but may result in overt diabetes mellitus or necessitate dose changes in insulin or other hypoglycemic agents. Letermovir: Moderate Frequently monitor blood glucose concentrations and for evidence of hypoglycemia during concurrent use of repaglinide and letermovir. Pegvisomant increases sensitivity to insulin by lowering the activity of growth hormone, and in some patients glucose tolerance improves with treatment. What are the possible side effects of repaglinide? Structural Formula of Repaglinide. Seek emergency medical attention or call the Poison Help line at Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. The major metabolites are an oxidized dicarboxylic acid M2the aromatic amine M1and the acyl glucuronide M7. Repaglinide Side Effects. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Repaglinide is a meglitinide antidiabetic. Your name. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. In this article About repaglinide Before taking repaglinide How to take repaglinide Getting the most from your treatment Can repaglinide cause problems? Plasma insulin levels increased after meals and reverted toward baseline before the next meal. In a double-blind, placebo-controlled, 3-month dose titration study, PRANDIN or placebo doses for each patient were increased weekly from 0. This dose may need to be increased after one or two weeks. In animal studies, pregnant animals were given this medication and had some babies born with problems. Hypoglycemia, upper respiratory infection, headache, diarrhea, constipation, arthralgia, back or chest pain. This is a condition in which your blood has a lower than normal number of blood cell fragments called platelets. Using certain medicines can make it harder for you to tell when you have low blood sugar. I was blindsided and completely missed this because I was focused on the patient at hand. What tips would you provide a friend before taking Prandin? In some patients with generalized dystonia who are unresponsive to medication, surgery may be used to help control symptoms. Advertisement - Continue Reading Below. Other options include, either protecting them with flea medications or deworming for tapeworms every 3 months. You can opt out at any time or find out more by reading our cookie policy. Sign up today - membership is free! What is repaglinide? This is more likely to occur if you take it with metformin or other antidiabetic medicines. Tell your doctor if you are breastfeeding or plan to breastfeed. Your doctor may want you to stop taking repaglinide for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency. Its quick onset and short duration of action concentrates its effect around meal time glucose load, which is important to the treatment of Type 2 diabetes. Authorisation details. Corticosteroids stimulate hepatic glucose production and inhibit peripheral glucose uptake into muscle and fatty tissues, producing insulin resistance. Sofosbuvir; Pranin Voxilaprevir: Moderate Closely monitor blood glucose levels if sofosbuvir is administered with antidiabetic agents. Patients on antidiabetic agents should be monitored for the need for dosage adjustments during PPrandin use of pentamidine. In the past, models of epileptic seizures Prnadin by focal administration of penicillin were frequently used to study various cellular epileptic phenomena; however, it is currently used much less frequently. Possible mechanisms include atypical antipsychotic-induced insulin resistance or direct beta-cell inhibition. Conjugated Estrogens: Minor Patients receiving antidiabetic agents should be periodically monitored for changes in glycemic control when hormone therapy is instituted or discontinued. Visit your doctor regularly. The hyperglycemic effect begins within an hour and generally lasts no more than 8 hours in the presence of normal renal function. The dose is adjusted to give the best control. Pegvisomant: Moderate Monitor blood glucose levels regularly in patients with diabetes, especially when pegvisomant treatment is initiated or when the dose is altered. You shouldn't take repaglinide if you have type 1 diabetes the body doesn't produce any insulin or diabetic ketoacidosis a dangerous condition that can occur if high blood sugar is untreated. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Blood glucose concentrations should be monitored more closely whenever a change in either nicotine intake or smoking status occurs; dosage adjustments in antidiabetic agents may be needed. Terms and conditions of this offer are subject to change at the sole discretion of PetSmart. Increased glucose monitoring may be required. Monthly newsletter. Wait until your next meal. Thus, in this configuration the linear gradient can be defined as one where the density increases linearly with volume. Prandin is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Prandin helps the pancreas to produce more insulin at mealtimes and is Prandin to control type-2 diabetes. Changing any of these factors can affect your blood sugar levels. These may include cardiovascular diseases, such as heart attackstrokeand problems related to blood circulation; nerve damage; kidney disease; or eye conditions. Common adverse events include: [1]. It's used to treat people with type 2 diabetes who can't manage their condition by diet and exercise alone. You are therefore advised to be selective about which sections or pages you wish to print. This is not a complete list of Prandin side effects. How to store repaglinide Important information about all medicines. Follow your diet, medication, and exercise routines very closely. Especially tell your doctor if you: are allergic to any of its ingredients have a condition called diabetic ketoacidosis have type 1 diabetes have liver problems have heart problems have kidney problems are pregnant or breastfeeding Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Availability Prescription only. Skip to Content. FDA alerts for all medications. Keep bottles tightly closed. Embryotoxicity, abnormal limb development in rat fetusus was observed in female rats exposed to high doses Prajdin the last stage of pregnancy. Hydrocodone; Phenylephrine: Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. Aprepitant, Fosaprepitant: Prandun Use caution if repaglinide and aprepitant, fosaprepitant are used concurrently and monitor for an Pradnin in repaglinide-related adverse effects for several days after administration of a multi-day aprepitant regimen. Clearance of oral repaglinide did not change over the 0. If these drugs are used together, closely monitor for signs of adverse events. Carbinoxamine; Hydrocodone; Phenylephrine: Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. The recommended dose range of Prandin for the treatment of type 2 diabetes is 0. A clinically relevant increase in the plasma concentration of repaglinide may occur during concurrent administration with letermovir. Patients should be closely monitored for a minimum of 24 to 48 hours, since hypoglycemia may recur after apparent clinical recovery. Did you experience many side effects while taking this drug? Pentamidine: Moderate Pentamidine can be harmful to pancreatic cells. Chlorpromazine: Minor Phenothiazines, especially chlorpromazine, may increase blood glucose concentrations. How Supplied: Tabs—, Sofosbuvir; Velpatasvir: Moderate Closely monitor blood glucose levels if sofosbuvir is administered with antidiabetic agents. Although specific dose recommendations are not available, a lower dose of repaglinide may be required to reduce the risk of hypoglycemia in this setting. Acetaminophen; Guaifenesin; Phenylephrine: Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically. It was branded Prandin because its quick onset and short duration of action concentrates its effect around meal time the prandium was the Roman meal which is comparable to the modern lunch.
Common use

Prandin contains active component Repaglinide which is used to stimulate insulin secretion from the pancreas in treatment of type 2 of diabetes mellitus together with a diet therapy and physical activities including combined treatment with metformin.



Dosage and direction

The medication is taken orally 15-30 minutes before a meal usually 3 times a day. Dosage is administered individually. Initial recommended dose is 0.5 mg. The dose may be increased only after 1-2 weeks of treatment if blood glucose levels require it. The maximum single dose is 4 mg, maximal daily dose is 16 mg. If the patient has taken other oral diabetes drug the recommended initial dose is 1 mg.



Precautions

Inform your doctor or pharmacist if you have liver impairments, kidney failure or disorders. The medication should be used with cautiousness in weakened patients and in patients before future major surgery.



Contraindications

Hypersensitivity, diabetes mellitus type 1, diabetic ketoacidosis with or without coma, severe liver dysfunction and/or kidney disease, pregnancy, breast-feeding. Prandin cannot be used in children and patients older than 75 y.o.



Side effects

Hypoglycemia,visual acuity loss, dyspepsia, transient increase in liver enzymes, allergic reactions.



Drug interaction

Beta-blockers, chloramphenicol, indirect anticoagulants (coumarin derivatives), NSAIDs, probenecid, salicylates, MAO inhibitors, sulfonamides, alcohol, anabolic steroids increase, calcium channel blockers, corticosteroids, diuretics (especially thiazide), isoniazid, niacin, oral contraceptives, phenothiazines, phenytoin, sympathomimetics, thyroid hormones weaken the effects of Prandin. Erythromycin, ketoconazole and miconazole slow down metabolism of Prandin while barbiturates, carbamazepine and rifampin stimulate it.



Missed dose

Take the missed dose as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your schedule. Do not double dose this medication to make up the missed dose.



Overdose

Symptoms of overdose include: hypoglycemia (hunger, fatigue and weakness, headache, irritability, anxiety, drowsiness, restless sleep, nightmares, behavioral changes (similar to ones observed during alcohol intoxication), poor concentration, slurred speech, vision problems, confusion, pallor, nausea, palpitations, cramps, cold sweats, coma, etc.



Storage

Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Doxycycline

Active Ingredients:

  • Doxycycline

Action mechanism and therapeutic effect of the medication:

Doxycycline is half-synthetic tetracycline antibiotic with a broad spectrum of antibacterial activity. Doxycycline exerts bacteriostatic action associated with suppressing the synthesis of proteins on ribosomes in microbial cell. Doxycycline is active against aerobic gram-positive bacteria Staphylococcus spp, Bacillus anthracis, Listeria monocytogenes; aerobic bacteria:Clostridium spp.

Medical indications: Doxycycline is indicated for the treatment of infections caused by sysceptible microorganisms:

  • ENT infections
  • Gastrointestinal infections
  • Infections of the upper and lower respiratory system
  • Skin and soft tissue infections
  • Urogenital infections
  • Syphilis (when unable to take penicillin)
  • Some respiratory or urinary tract infections (UTIs)
  • Plague
  • Cholera
  • Certain types of pneumonia
  • Chlamydia
  • Rocky Mountain spotted fever
  • Tularemia
  • Typhus fever
  • Tick fever
  • Gonorrhea
  • Lyme disease
  • Anthrax infection treatment
  • Rosacea treatment
  • Gum disease treatment
  • Malaria treatment

Doxycyline contradictions, precautions and warnings:

Doxycycline is contraindicated for use in:

  • Hypersensitivity to doxycycline and other components of the medication
  • Severe liver diseases
  • Severe kidney diseases
  • History of pseudo-membranous colitis
  • Pregnancy (Doxycycline is a pregnancy category D meaning that it can cause significant damage to the fetus)
  • Breastfeeding
  • Frequent yeast infections

Doxycyline side effects:

As with any other drug, side effects can occur with Doxycyline. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. The most common Doxycycline side effects include:

  • Decreased appetite
  • Vomiting
  • Stomach pain
  • Heartburn
  • Diarrhea
  • Photo-sensitivity
  • Nausea

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Doxycyline, please talk to your doctor or pharmacist.

Drug interaction:

Doxycyline can potentially interact with the following groups of drugs:

  • Aluminum, calcium, magnesium, or iron products
  • Bile-acid sequestrant cholesterol drugs
  • Barbiturates
  • Peniccilins
  • Oral typhoid vaccine
  • Birth control pills
  • Anti-diarrheal drug (Bismuth subsalicylate)
  • Bipolar disorder treatment (Carbamazepine)
  • HIV treatment (Maraviroc)
  • Retinoids
  • Blood thinners (Warfarin)
  • ACE inhibitor (Quinapril)
  • Aldosterone antagonist (Eplerenone)
  • Opioid pain killer (Fentanyl)
  • Anticonvulsant (phenytoin)

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Doxycyline which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.