Generic Tegopen (Cloxacillin)
Tegopen
Tegopen is a penicillin type antibiotic prescribed in treatment of infections of respiratory and urinary tracts.
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Common use

Tegopen is an antibacterial medication from the group of semi-synthetic penicillins. It kills bacteria by blocking bacterial synthesis of cell wall and hereby prevents propagation of the microorganisms. It is active against gram-positive and gram-positive cocci: Neisseria meningitidis and Neisseria gonorrhoeae, Corynebacterium diphtheriae, Haemophilus influenzae, Bacillus anthracis. Tegopen is stable in acidic media and to the action of penicillinase. Cloxacillin is used to treat infectious and inflammatory diseases caused by the susceptible organisms such as abscesses, carbuncles, furunculosis, sinusitis, otitis media, pharyngitis, tonsillitis, paratonsillar abscess, pneumonia, pleural empyema, meningitis, endocarditis, sepsis, osteomyelitis, urinary tract diseases, prevention of complications on transplantation of skin graft.



Dosage and direction

Take exactly as prescribed by your doctor. Recommended dose for adults is 500 mg four times a day, one for 2-10 y.o. Kids is 250 mg four times a day, children younger than 2 y.o. should take 125 mg of Tegopen four times a day. Drink a full glass of water after you took each dose on an empty stomach at least one hour before or two hours after a meal. Do not drink soda or other carbonated beverages as they are able to decrease effectiveness of the treatment. Take this medication regularly at evenly spaced intervals to get the best results. Do not crush, chew, or open the capsules, just swallow them whole. If it is the suspension liquid of Tegopen shake it before usage and measure with a special spoon. Do not stop taking this medication without recommendation of your doctor even if your symptoms improved as your infection may not be completely treated.



Precautions

Inform your doctor if you have such conditions as kidney disease, stomach or intestinal illnesses, infectious mononucleosis, diabetes, or allergic to any penicillines. Avoid taking alcohol if you are treated with Tegopen as it is able to worsen its side effects.



Contraindications

Hypersensitivity to the components of Tegopen.



Possible side effect

If during treatment with Tegopen you experience hives, itching, nausea, heartburn, diarrhea, anaphylactic shock, seizures, severe watery diarrhea and abdominal cramps, unusual bleeding or bruising just stop taking it and notify your doctor about your symptoms as you may need immediate medical help.

Drug interaction

Antacids, glucosamine, laxatives, food, aminoglycosides slow down and reduce absorption of Tegopen while ascorbic acid increases it. Co-administration of bactericidal antibiotics (including cephalosporin, cycloserine, vancomycin, rifampin), aminoglycosides co-administered with Tegopen has a combined effect, which exceeds the action of each separate component. Tegopen is an antagonist toward bacteriostatic antibiotics (including macrolides, chloramphenicol, linkosamidy, tetracyclines). Tegopen increases effectiveness of anticoagulants by suppressing the intestinal microflora, reducing prothrombin index. It reduces effectiveness of oral contraceptives. Diuretics, allopurinol, blockers of tubular secretion, phenylbutazone, NSAIDs which decrease the tubular secretion, increase blood levels of Tegopen. Concomitant use with allopurinol increases risk of allergic reactions (rash).



Missed dose

If you forgot to take this medication take it as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your regular schedule.



Overdose

In case you experience muscle spasms or weakness, pain or twitching, ache in the fingers or toes, numbness in the fingers or toes, seizures, confusion, coma, or agitation during treatment with Tegopen, seek for immediate medical help.



Storage

Store Tegopen capsules at room temperature. Tegopen suspension should be kept in the refrigerator for longer use. The suspension is valid for 14 days if it is stored in the refrigerator. Do not use any remnants of the liquid after this amount of time.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Doxycycline

Active Ingredients:

  • Doxycycline

Action mechanism and therapeutic effect of the medication:

Doxycycline is half-synthetic tetracycline antibiotic with a broad spectrum of antibacterial activity. Doxycycline exerts bacteriostatic action associated with suppressing the synthesis of proteins on ribosomes in microbial cell. Doxycycline is active against aerobic gram-positive bacteria Staphylococcus spp, Bacillus anthracis, Listeria monocytogenes; aerobic bacteria:Clostridium spp.

Medical indications: Doxycycline is indicated for the treatment of infections caused by sysceptible microorganisms:

  • ENT infections
  • Gastrointestinal infections
  • Infections of the upper and lower respiratory system
  • Skin and soft tissue infections
  • Urogenital infections
  • Syphilis (when unable to take penicillin)
  • Some respiratory or urinary tract infections (UTIs)
  • Plague
  • Cholera
  • Certain types of pneumonia
  • Chlamydia
  • Rocky Mountain spotted fever
  • Tularemia
  • Typhus fever
  • Tick fever
  • Gonorrhea
  • Lyme disease
  • Anthrax infection treatment
  • Rosacea treatment
  • Gum disease treatment
  • Malaria treatment

Doxycyline contradictions, precautions and warnings:

Doxycycline is contraindicated for use in:

  • Hypersensitivity to doxycycline and other components of the medication
  • Severe liver diseases
  • Severe kidney diseases
  • History of pseudo-membranous colitis
  • Pregnancy (Doxycycline is a pregnancy category D meaning that it can cause significant damage to the fetus)
  • Breastfeeding
  • Frequent yeast infections

Doxycyline side effects:

As with any other drug, side effects can occur with Doxycyline. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. The most common Doxycycline side effects include:

  • Decreased appetite
  • Vomiting
  • Stomach pain
  • Heartburn
  • Diarrhea
  • Photo-sensitivity
  • Nausea

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Doxycyline, please talk to your doctor or pharmacist.

Drug interaction:

Doxycyline can potentially interact with the following groups of drugs:

  • Aluminum, calcium, magnesium, or iron products
  • Bile-acid sequestrant cholesterol drugs
  • Barbiturates
  • Peniccilins
  • Oral typhoid vaccine
  • Birth control pills
  • Anti-diarrheal drug (Bismuth subsalicylate)
  • Bipolar disorder treatment (Carbamazepine)
  • HIV treatment (Maraviroc)
  • Retinoids
  • Blood thinners (Warfarin)
  • ACE inhibitor (Quinapril)
  • Aldosterone antagonist (Eplerenone)
  • Opioid pain killer (Fentanyl)
  • Anticonvulsant (phenytoin)

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Doxycyline which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.