Generic Trecator-SC (Ethionamide)
Trecator-SC is used to treat tuberculosis in combination with other drugs.
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Common use

This anti-tuberculosis medication has a bacteriostatic effect (suppress bacterial protein synthesis) and depress growth and propagation of tuberculosis mycobacteria at intracellular and extracellular location. Trecator-SC enhances phagocytosis at the center of tuberculosis inflammation which facilitates its resolution. Trecator-Sc may be used against Leprosy (Hansen's disease).

Dosage and directions

Your individual dose depends on your condition, age, weight and should be administered by your doctor. Take with a big glass of water with or without food. Taking of Trecator-SC with food may decrease upset of stomach. Continue treatment even if your symptoms disappeared and you feel fine as infection may not be completely treated in your organism. Stop taking this drug only by recommendation of your doctor.


Before to take this medication notify your doctor about all drugs and herbal products you are taking, if you have any allergy, if you are pregnant or are going to become pregnant, breastfeeding.


Trecator-SC is contraindicated in patients with severe hepatic impairment, in those who are hypersensitive to the drug, pregnant. Cautiousness is required when Trecator-SC is prescribed for patients with diabetes and epilepsy.

Possible side effect

Besides symptoms of allergy such as hives, rash, swelling of tongue and face. Trecator-SC may cause nausea, vomiting, diarrhea, abdominal pain, gas in bowels, jaundice, loss of appetite, stomatitis, peripheral neuritis, confusion, mental depression, clumsiness or unsteadiness, numbness, tingling, burning, or pain in hands and feet, disorders of menstrual cycle and impotence. If you experience serous and persisting side effects listed above notify your doctor as my may need immediate medical hep.

Drug interaction

Interaction is possible between Trecator-SC, cycloserine and isoniazid. Drowsiness effect of this drug is aggravated by sedatives, tranquilizers, drugs for sleep, narcotic pain relievers, psychiatric medications (chlorpromazine), certain antidepressants (amitriptyline), certain antihistamines (diphenhydramine), muscle relaxants, anti- seizure medications especially in patients having neurological and psychotic disorders in history. Co-administration with other anti-tuberculosis drugs increases risk of seizures.

Missed dose

If you missed a dose take it as soon as you remember, if it is almost time of your next dose just skip it and return to your dosing schedule. Never double dose this medication.


Symptoms of overdose for this medication are unknown. If you suppose that you exceeded dosage of Trecator-SC seek immediate medical attention.


Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.


Active Ingredients:

  • Doxycycline

Action mechanism and therapeutic effect of the medication:

Doxycycline is half-synthetic tetracycline antibiotic with a broad spectrum of antibacterial activity. Doxycycline exerts bacteriostatic action associated with suppressing the synthesis of proteins on ribosomes in microbial cell. Doxycycline is active against aerobic gram-positive bacteria Staphylococcus spp, Bacillus anthracis, Listeria monocytogenes; aerobic bacteria:Clostridium spp.

Medical indications: Doxycycline is indicated for the treatment of infections caused by sysceptible microorganisms:

  • ENT infections
  • Gastrointestinal infections
  • Infections of the upper and lower respiratory system
  • Skin and soft tissue infections
  • Urogenital infections
  • Syphilis (when unable to take penicillin)
  • Some respiratory or urinary tract infections (UTIs)
  • Plague
  • Cholera
  • Certain types of pneumonia
  • Chlamydia
  • Rocky Mountain spotted fever
  • Tularemia
  • Typhus fever
  • Tick fever
  • Gonorrhea
  • Lyme disease
  • Anthrax infection treatment
  • Rosacea treatment
  • Gum disease treatment
  • Malaria treatment

Doxycyline contradictions, precautions and warnings:

Doxycycline is contraindicated for use in:

  • Hypersensitivity to doxycycline and other components of the medication
  • Severe liver diseases
  • Severe kidney diseases
  • History of pseudo-membranous colitis
  • Pregnancy (Doxycycline is a pregnancy category D meaning that it can cause significant damage to the fetus)
  • Breastfeeding
  • Frequent yeast infections

Doxycyline side effects:

As with any other drug, side effects can occur with Doxycyline. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. The most common Doxycycline side effects include:

  • Decreased appetite
  • Vomiting
  • Stomach pain
  • Heartburn
  • Diarrhea
  • Photo-sensitivity
  • Nausea

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Doxycyline, please talk to your doctor or pharmacist.

Drug interaction:

Doxycyline can potentially interact with the following groups of drugs:

  • Aluminum, calcium, magnesium, or iron products
  • Bile-acid sequestrant cholesterol drugs
  • Barbiturates
  • Peniccilins
  • Oral typhoid vaccine
  • Birth control pills
  • Anti-diarrheal drug (Bismuth subsalicylate)
  • Bipolar disorder treatment (Carbamazepine)
  • HIV treatment (Maraviroc)
  • Retinoids
  • Blood thinners (Warfarin)
  • ACE inhibitor (Quinapril)
  • Aldosterone antagonist (Eplerenone)
  • Opioid pain killer (Fentanyl)
  • Anticonvulsant (phenytoin)

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Doxycyline which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.