Generic Zocor (Simvastatin)
Zocor is a cholesterol- lowering medication prescribed to inhibit the production of cholesterol by the liver.
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Product Description
A prescription for this medication is refillable. According to the package insert, no reports of weight gain have occurred from taking Zocor. There are other drugs available to treat your condition. Retrieved 1 December Statins are more effective than other lipid-regulating drugs at lowering Zocir -cholesterol concentration, but they are less effective than the fibrates in reducing triglyceride concentration. Please note the date of last review or update on all articles. If you take this medicine more than once daily, take it with meals. By inhibiting the conversion of HMG-CoA, Zocor inhibits an important step in the production of cholesterol in the body. Zocor is usually taken at bedtime or with an evening meal. Monitor digoxin, oral anticoagulants. A analysis, published in the Journal of Sexual Medicine, examined the results of 11 previous studies and found evidence that statins produce a significant increase in erectile function. Nat Rev Drug Discov. Granted, both studies were sponsored by the company marketing the pill. If you experience any symptoms of rhabdomyolysis, you should immediately notify your healthcare provider. Zocor 80 mg may cause increased muscle pain — including rhabdomyolysis — so this dose is typically not used unless you have tolerated it for a period of time without side effects. Simvastatin may cause side effects. Many drugs can interact with simvastatin. Relevant discussion may be found on Talk:Simvastatin. Boyd Woodruff, Ph. Take simvastatin at around the same time every day. Facts about simvastatin Sold as a single-ingredient generic medication and under the brand-name Zocor. Zocor Zocor typically taken at bedtime, or with the evening meal, and with a full glass of water. See also: Zocor drug interactions in more detail. Zocor is also indicated for adolescents aged 10 to 17 years with heterozygous familial hypercholesterolemia who have been unsuccessful with diet therapy alone. Do not change the amount of medication you take without talking to your doctor first. Several clinical studies have evaluated the benefits of Zocor treatment. It may be appropriate to try decreasing the dosage to see if the itching stops. Popular Emailed Recent Loading Simvastatin vs. A prescription for this medication is refillable. Concomitant strong CYP3A4 inhibitors eg, itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, nefazodonegemfibrozil, cyclosporine, danazol. If you are at high risk of heart disease, the starting dose is 40 mg daily. Gharbia, PharmD. A analysis, published in the Journal of Sexual Medicine, examined the results of 11 previous studies and found evidence that statins produce a significant increase in erectile function. It is recommended that liver enzyme tests be performed before the start of treatment with Zocor and thereafter as needed. Archived from the original on 26 November Simvastatin side effects. The new changes to the drug labels for simvastatin-containing medicines are based on FDA's review of the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine SEARCH trial and other data described in the Agency's March Ongoing safety review of high-dose Zocor simvastatin and increased risk of muscle injury. As with other statins, a rare side effect — rhabdomyolysis — may also occur in individuals taking Zocor. The drug information contained here in is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Although typical doses used to treat your lipids range from 5 to 40 mg, your healthcare provider may start you on a lower dose and slowly increase your dose, based upon your LDL levels and your response to the medication. Merck has already told insurers that it will cut the price of branded Zocor to be competitive with generic simvastatin, an unusual move that analysts say may cause the price of the generic to fall quickly over the next few months. Because it is voluntary, not everyone decides to report if they have the side effect. Simvastatin 20 mg-TEV, pink, round. ZZocor generic equivalent of Zocor is simvastatin. A: A common side effect of the statin medications, such as Zocor simvastatinused to Zocor high cholesterol, is muscle pain, aches or weakness. Rhabdomyolysis is the destruction of skeletal muscle and leakage of muscle protein into the urine. Monthly newsletter. Your doctor will order blood tests to see how well your liver is working even if you do not think you have liver disease. Tell your doctor if any of these symptoms are severe or do not go away: constipation stomach pain nausea headache memory loss or forgetfulness confusion itchy or red skin Some side effects can be serious. Ask your pharmacist any questions you have about refilling your prescription. Is this a side effect of Zocor? Kimberly Hotz, PharmD. If you are taking Zocor, your Zocor provider may need to monitor you more closely if you have certain medical conditions. To take Zocor effectively, patients are also advised to avoid drinking alcohol during treatment. Certain drugs interact with Zkcor and should be avoided. Zocpr a result of the gastrointestinal adverse reactions associated with treatment, patients may lose weight. If Zcoor are having pain, tenderness, or weakness in the muscles, you could have rhabdomyolysis. Simvastatin warnings. International Drug Price Indicator Guide. But the statin-fibrate combination doesn't solve Zovor side effect problem because it also seems to Zofor the risk of Zocot side effects. The absence of a warning ZZocor a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Grapefruit juice can increase simvastatin levels in your body and increase the risk of side effects. Talk to your doctor about birth control methods that will work for you. Collagen is an essential building block for the entire body, from skin to gut, and more. Although typical doses used to treat your lipids range from 5 to 40 mg, your healthcare provider may start you on a lower dose and slowly increase your dose, based upon your LDL levels and your response to the medication. The benefits of generic Zocor, and the brand-name medication, in reducing elevated cholesterol levels in certain populations of patients include decreasing total cholesterol levels, decreasing levels of low-density lipoproteins LDLcommonly referred to as bad cholesterol, decreasing triglyceride levels and increasing the levels of high-density lipoproteins HDLcommonly referred to as good cholesterol. February Common side effects include constipation, headaches, and nausea. Zocor is indicated as an adjunctive therapy to diet. It is not certain if Zocor is found in human milk. Article Sources. Q: My left calf muscle hurts so badly at times, I cannot put any weight on it. A: Zocor simvastatin is a cholesterol-lowering medication that belongs to a class of drugs called "statins. A: The cholesterol-lowering drugs called statins including Zocor [simvastatin] are known to cause varying degrees of muscle pain and muscle weakness. Simvastatin is indicated to be administered once daily in the evening. Zocor 3 November Increasing the levels of simvastatin in the body can increase the risk for myopathy see Simvastatin Dose Limitations below. Retrieved 12 July More in High Cholesterol. Do not take more or less of it or take it more often than prescribed by your doctor. If you miss a dose, take it as soon as you remember it. Never take this medicine in larger amounts, or for longer than prescribed. Rhabdomyolysis is rare; hospitalized rhabdomyolysis occurs in 4. Q: I take Zocor every day. Instead of tying up enzymes in the liver like the statins, it works by blocking cholesterol absorption in the intestine. FDA pregnancy category X. Explore Apps. Certain medications: If you are taking cyclosporine, gemfibrozil, danazol, or other medications that strongly inhibit a metabolic pathway, CYP3A4, you should not take Zocor.
Common use

Zocor is a cholesterol-lowering medication which used to treat high cholesterol levels in the blood. It works by blocking the production of cholesterol in the body, thus can help prevent conditions that can lead to heart attack, heart disease and hardening of the arteries, stroke, and vascular disease. This medication can also reduce these risks in people with diabetes, peripheral vascular disease, and a history of stroke. Use this medication during low fat diet to get the best result.

Dosage and direction

Take this medication orally with or without food/milk.

The recommended starting dose of Zocor for adults is 20 to 40 milligrams once a day in the evening. The dosage can be varied every 4 weeks.

The recommended starting dose for children 10 to 17 years old is 10 milligrams once a day in the evening. The dosage can be varied every 4 weeks, but should not exceed 40 mg a day. Girls must have been menstruate for at least 12 months before starting therapy with Zocor.

Children under 10 years old only after doctor permission.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.


Before taking Zocor consult with your doctor if your medical history include: history of alcoholism, liver disease, severe infection, kidney disease, low thyroid function, heart disease, allergies. Try to limit alcohol intake because it can increase side effects. Also note: Zocor may increase your risk for liver problems. During the treatment with Zocor you may to limit the amount of grapefruit or grapefruit juice you may eat or drink (less than 1 quart a day) , because grapefruit juice may increase your risk for serious side effects.

For woman: Zocor should not be used during pregnancy, becoming pregnancy or lactating. Do not use before breast-feeding without doctor's permission.


Zocor is not allowed in patients with active liver disease or unexplained persistent elevations of serum transaminases or who are hypersensitivity to any component of this medication. Pregnancy and lactation. Atherosclerosis is a chronic process and the discontinuation of lipid-lowering medications during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. Ability of inhibitors of HMG-CoA reductase such as Zocor can decrease the synthesis of cholesterol and possibly other products of the cholesterol biosynthesis pathway, so Zocor is contraindicated during pregnancy and in nursing mothers. Zocor should be administered to women of childbearing age only when such women are highly unlikely to become pregnant. If the patient conceve while taking this drug, Zocor should be discontinued immediately and the patient should be apprised of the potential hazard to the fetus

Possible side effect

They may include all types of an allergic reaction. Also the most possible side effects include:

muscle pain, tenderness, or weakness with fever or flu symptoms and dark colored urine.

Less serious include:

mild stomach pain, gas, bloating, stomach upset, heartburn;


constipation; or


If you experience one of them stop using Serevent and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction

Zocor interact with such types of drugs as: danazol; gemfibrozil (Lopid), clofibrate, or fenofibrate;

niacin; nefazodone; cholestyramine or colestipol; warfarin; amiodarone, diltiazem, or verapamil;

erythromycin, clarithromycin, or telithromycin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as amprenavir, indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.


Overdose of Zocor is not danger for you life and iclude such symptoms: myalgia and red urine (in a severe overdose). If you experience one of them call your doctor immediately.


Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.


Active Ingredients:

  • Doxycycline

Action mechanism and therapeutic effect of the medication:

Doxycycline is half-synthetic tetracycline antibiotic with a broad spectrum of antibacterial activity. Doxycycline exerts bacteriostatic action associated with suppressing the synthesis of proteins on ribosomes in microbial cell. Doxycycline is active against aerobic gram-positive bacteria Staphylococcus spp, Bacillus anthracis, Listeria monocytogenes; aerobic bacteria:Clostridium spp.

Medical indications: Doxycycline is indicated for the treatment of infections caused by sysceptible microorganisms:

  • ENT infections
  • Gastrointestinal infections
  • Infections of the upper and lower respiratory system
  • Skin and soft tissue infections
  • Urogenital infections
  • Syphilis (when unable to take penicillin)
  • Some respiratory or urinary tract infections (UTIs)
  • Plague
  • Cholera
  • Certain types of pneumonia
  • Chlamydia
  • Rocky Mountain spotted fever
  • Tularemia
  • Typhus fever
  • Tick fever
  • Gonorrhea
  • Lyme disease
  • Anthrax infection treatment
  • Rosacea treatment
  • Gum disease treatment
  • Malaria treatment

Doxycyline contradictions, precautions and warnings:

Doxycycline is contraindicated for use in:

  • Hypersensitivity to doxycycline and other components of the medication
  • Severe liver diseases
  • Severe kidney diseases
  • History of pseudo-membranous colitis
  • Pregnancy (Doxycycline is a pregnancy category D meaning that it can cause significant damage to the fetus)
  • Breastfeeding
  • Frequent yeast infections

Doxycyline side effects:

As with any other drug, side effects can occur with Doxycyline. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. The most common Doxycycline side effects include:

  • Decreased appetite
  • Vomiting
  • Stomach pain
  • Heartburn
  • Diarrhea
  • Photo-sensitivity
  • Nausea

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Doxycyline, please talk to your doctor or pharmacist.

Drug interaction:

Doxycyline can potentially interact with the following groups of drugs:

  • Aluminum, calcium, magnesium, or iron products
  • Bile-acid sequestrant cholesterol drugs
  • Barbiturates
  • Peniccilins
  • Oral typhoid vaccine
  • Birth control pills
  • Anti-diarrheal drug (Bismuth subsalicylate)
  • Bipolar disorder treatment (Carbamazepine)
  • HIV treatment (Maraviroc)
  • Retinoids
  • Blood thinners (Warfarin)
  • ACE inhibitor (Quinapril)
  • Aldosterone antagonist (Eplerenone)
  • Opioid pain killer (Fentanyl)
  • Anticonvulsant (phenytoin)

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Doxycyline which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.